---
product_id: 3403169
title: "Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply"
brand: "advantage"
price: "644 Lei"
currency: RON
in_stock: true
reviews_count: 8
category: "Advantage"
url: https://www.desertcart.ro/products/3403169-advantage-ii-large-dog-vet-recommended-flea-treatment-and-prevention
store_origin: RO
region: Romania
---

# Waterproof after 24 hours Kills fleas in 12 hours 30-day continuous protection Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply

**Brand:** advantage
**Price:** 644 Lei
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of fleas—because your dog deserves the best defense!

## Quick Answers

- **What is this?** Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply by advantage
- **How much does it cost?** 644 Lei with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.ro](https://www.desertcart.ro/products/3403169-advantage-ii-large-dog-vet-recommended-flea-treatment-and-prevention)

## Best For

- advantage enthusiasts

## Why This Product

- Trusted advantage brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Month-Long Defense:** Keeps your dog flea-free for a full 30 days with one easy application.
- • **Effortless Application:** Topical spot-on treatment that’s quick, mess-free, and prescription-free.
- • **Rapid Flea Eradication:** Starts killing fleas within 12 hours—no more waiting around!
- • **Vet-Recommended Formula:** Trusted by professionals for safe, effective flea and lice control.
- • **Active Outdoor Lifestyle Ready:** Waterproof after 24 hours so your dog can keep exploring without interruption.

## Overview

Advantage II for Dogs is a vet-recommended, fragrance-free topical flea treatment designed for dogs weighing 21 to 55 lbs and aged 7 weeks or older. It kills adult fleas, larvae, and eggs within 12 hours and provides continuous protection for 30 days. Waterproof after 24 hours, this easy-to-apply formula breaks the flea life cycle, preventing infestations and associated health risks without the need for a prescription.

## Description

Product Description Advantage II Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21 to 55 lbs. to use Advantage II Large Dog.For the ultimate convenience in care, Advantage II Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.Advantage II Large Dog is a trademark of Elanco or its affiliates. Brand Story By Advantage

Review: No fleas, no ticks - Works for all 3 of my dogs, no fleas, no ticks! I buy this product every summer!
Review: Works Great - While others claimed to rid fleas this one actually delivered control within 72 hours of application

## Features

- Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age
- Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
- Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
- Easy-to-apply topical treatment, no prescription needed
- Fragrance-free formula, waterproof after 24 hours

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B004QMX59Q |
| ASIN  | B004QMX59Q |
| Age Range Description | 7 weeks and older |
| Best Sellers Rank | #9,835 in Pet Supplies ( See Top 100 in Pet Supplies ) #48 in Dog Flea Drops |
| Brand Name | Advantage |
| Breed Recommendation | Large |
| Care Instructions | Topical Treatment |
| Color | Blacks & Grays |
| Country of Origin | Germany |
| Customer Reviews | 4.5 4.5 out of 5 stars (4,593) |
| Date First Available | December 20, 2002 |
| Date First Available  | December 20, 2002 |
| Department | Flea & Tick |
| Department  | Flea & Tick |
| Directions | Application Instructions: 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until… |
| Is Discontinued By Manufacturer  | No |
| Item Dimensions LxWxH | 1.38 x 4.38 x 6.63 inches |
| Item Package Dimensions L x W x H | 6.61 x 4.33 x 1.44 inches |
| Item Weight | 1.6 ounces |
| Item model number | 86336685 |
| Item model number  | 86336685 |
| Manufacturer | Elanco US Inc |
| Manufacturer  | Elanco US Inc |
| Manufacturer recommended age  | 1 month and up |
| Material | Cotton |
| Model Name | Advantage II |
| Number of Items | 6 |
| Product Dimensions  | 1.38 x 4.38 x 6.63 inches; 1.6 ounces |
| Size | 6-Pack |
| Specific Uses for Product | Parasites |
| Style | 6 doses |
| Target Audience Keyword | dogs |

## Product Details

- **Active Ingredients:** Imidacloprid, Pyriproxyfen
- **Age Range (Description):** 7 weeks and older
- **Allergen Information:** Allergen-Free
- **Brand:** Advantage
- **Dog Breed Size:** Large
- **Item Form:** Topical
- **Item Volume:** 15 Milliliters
- **Item Weight:** 1.6 ounces
- **Scent:** Unscented
- **UPC:** 724089202918 724089617668

## Images

![Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply - Image 1](https://m.media-amazon.com/images/I/71F-RThwJ-L.jpg)

## Questions & Answers

**Q: Is there a warning to keep the dog away from cats for 24 hours after treatment with Advantage, as is found on Frontline?**
A: Yes, there is a seperate and specific warning about not using it on cats and keeping dogs away from cats for 24 hrs. Highlited in yellow.

**Q: Is it ok to put advantix and advantage ii simultaneously on a larger dog? advantix for l and advantage ii for sm.  that amount needed for bigger dog.**
A: Each box will have a different expiration date on it. We had a box for at least a year, it still worked on the dog.

**Q: What are ingredients?**
A: Strange that they leave this part out of the description as it is rather important. I have used this product on several dogs for years and purchased here and the online pet pharmacy out of Canada (wife ordered and I forget the name) but never had a problem but just like humans, some dogs have different reactions than others to certain products/chemicals, so do be careful to follow directions and monitor a bit to make sure your pet is taking it as expected and not having any reactions.  Since they don't list it, I would email them seller directly, and/or look on the manufacturer website for more info.

**Q: what is the difference between Advantage 11 and Advantage?**
A: Advantage II Is a better flea control and does not wash off as does Advantage.  Advantage II is what you want!

## Customer Reviews

### ⭐⭐⭐⭐⭐ No fleas, no ticks
*by J***R on December 5, 2025*

Works for all 3 of my dogs, no fleas, no ticks! I buy this product every summer!

### ⭐⭐⭐⭐⭐ Works Great
*by A***R on January 5, 2026*

While others claimed to rid fleas this one actually delivered control within 72 hours of application

### ⭐⭐⭐⭐⭐ Great job
*by M***R on January 2, 2026*

Great job

## Frequently Bought Together

- Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply
- Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply
- Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply

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*Product available on Desertcart Romania*
*Store origin: RO*
*Last updated: 2026-01-28*