--- product_id: 43039649 title: "Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets" brand: "extreme v" price: "591 Lei" currency: RON in_stock: true reviews_count: 8 category: "Extreme V" url: https://www.desertcart.ro/products/43039649-azendus-sam-e-mood-support-400mg-60-count-same-butanedisulfonate store_origin: RO region: Romania --- # 400mg potent SAMe dose Individually foil-sealed for freshness Enteric coated for max bioavailability Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets **Brand:** extreme v **Price:** 591 Lei **Availability:** ✅ In Stock ## Summary > 💡 Elevate your mood naturally — because your brain deserves premium care. ## Quick Answers - **What is this?** Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets by extreme v - **How much does it cost?** 591 Lei with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.ro](https://www.desertcart.ro/products/43039649-azendus-sam-e-mood-support-400mg-60-count-same-butanedisulfonate) ## Best For - extreme v enthusiasts ## Why This Product - Trusted extreme v brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Advanced Enteric Coating:** Protects SAMe from stomach acid, ensuring maximum absorption where it counts. - • **Freshness-Sealed Foil Packs:** Each tablet is individually wrapped to preserve stability and potency until the last dose. - • **Clinically Potent 400mg Dose:** Delivers a powerful, plant-based SAMe boost to support mood and neurotransmitter synthesis. - • **Trusted Brand with Responsive Service:** Azendus’ commitment to quality and customer care means you never run out of your mood support. - • **Natural Mood Support Without Side Effects:** Helps regulate serotonin, dopamine, and norepinephrine without weight gain or sexual dysfunction. ## Overview Extreme V Azendus SAM-e Mood Support offers a potent 400mg dose of natural SAMe-Butanedisulfonate in enteric-coated, foil-sealed tablets designed for superior bioavailability and stability. This plant-based supplement supports neurotransmitter production critical for mood regulation without common side effects like weight gain or sexual dysfunction. Trusted by users for its effectiveness and backed by responsive customer service, it’s a premium choice for professionals seeking natural, reliable mood enhancement. ## Description Product description Azendus supports the replenishment of S-Adenosylmethionine levels and balances the interactions of your immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body.* FOR MOOD Azendus supports brain function and brain cell neuronal health by boosting levels of neuroprotective compounds L-Glutathione (GSH) & Superoxide DismutaseaSOD). SAMe's ability to both sustain emotional well-being and combat brain aging has been established by leading universities and medical organizations.* FOR JOINT Azendus reduces sensitivity and stiffness in aging individuals and helps support healthy joints. SAMe can stimulate the reproduction of joint connective tissue and improve cartilage function-the key to reversing joint sensitivity and discomfort.* FOR LIVER Azendus significantly increases the liver’s glutathione level. This is critical because glutathione is the chief antioxidant produced in the liver, also known as the “super antioxidant”. Age, stress, free radicals and environmental conditions can dramatically impact the liver’s health and accelerate the aging process. SAMe is converted into glutathione, thus having the therapeutic benefits for the liver to combat oxidative stress, cellular damage, free radical activity and DNA breakdown, allowing the body to detoxify Azendus is formulated with Pharmaceutical Grade S-Adendosylmethionine Butanedisulfonate. SAM-e is made naturally by microbiological fermentation and then specially processed in a ultra-low moisture and temperature controlled clean-room to preserve 68-80% (S,S) SAMe, the highest active level available. Azendus plant based enteric coating is formulated to pH release in the small intestine for maximum bioavailability and absorption.* Azendus is the only SAMe with a Natural Plant based coating. No plastic co-polymer coating material- only pure Pharmaceutical Grade SAMe and Gentle Plant derived enteric coating materials.* Azendus is packaged in individual tamper proof foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken. For Liver SAMe significantly increases the liver’s glutathione level. This is critical because glutathione is the chief antioxidant produced in the liver, also known as the “super antioxidant”. Age, stress, free radicals and environmental conditions can dramatically impact the liver’s health and accelerate the aging process. SAMe is converted into glutathione, thus having the therapeutic benefits for the liver to combat oxidative stress, cellular damage, free radical activity and DNA breakdown, allowing the body to detoxify.* For Mood SAMe supports brain function and brain cell neuronal health by boosting levels of neuroprotective compounds L-Glutathione (GSH) & Superoxide DismutaseaSOD). SAMe's ability to both sustain emotional well-being and combat brain aging has been established by leading universities and medical organizations. For Joint Azendus is the only SAMe with a Natural Plant based coating- only pure Pharmaceutical Grade SAMe and Gentle Plant derived enteric coating materials Review: How SAMe compares to longtime antidepressants - Taking 2 of the 400mg dose each morning for anxiety/depression (in other countries where SAM-e can be prescribed for such problems, 800mg is the standard MINIMUM dose and lower doses are usually ineffective). I’ve been on antidepressants of all different brands/kinds for 10 years now and they all have heavy side effects. Ultimately being emotionally blunted and losing any sense of motivation to do things I had to or even wanted to is what made me decide I had enough. However the nature of my particular problems are too serious to leave unchecked, so I started using this as soon as I worked down and got off the antidepressant, working up from the smallest dose over a month or two (be sure you’re off serotonin-altering medications like SSRIs or SNRIs before you start). Note that it will likely take a month or more to kick in, just like serotonin-altering medications. I chose this brand because it came up in research as one of the better brands you can get in the U.S., as it uses butanedisulfonate instead of the poorer quality tosylate that more commonly seen brands use (which were the ones I was familiar with from past dabbling at 200mg doses). I wish it wasn’t so costly but alas. Know that the 400mg pill is bigger than the 200mg one, multivitamin size. Unfortunately the 200 and 400mg boxes have no difference in box branding so make sure you’re getting the right dose and number of pills. I still have to take a different, non-antidepressant medication for a couple of the anxiety/sleep disorders, but the SAM-e has definitely taken the sharp edge off my anxiety and kept major depression away even through a very distressing life change, and without any noticeable side effects. It gives you enough help to keep you sane but doesn’t zombify you, letting you feel emotions (even if that can be hard at times) and learn coping strategies and healthy management of your disorders so that they can’t run your life anymore. Instead of being crutches like antidepressants, SAM-e is a handrail. You have to stand on your own two feet but you still have help so you don’t fall. Drugs are certainly stronger, but at more personal cost. What makes me like Azendus specifically is that when they accidentally sent me the wrong dosage and count days before I was about to run out they immediately got back to my return request (within an hour), refunded me, and sent me more with priority shipping at no cost to me. They were low on stock with the specific dose/count I typically get so they sent me enough of the 30 count to match up to my usual 60 count. I was very relieved and impressed by that and will definitely continue using this brand despite the lack of Prime shipping because I trust that honesty and reliability and that’s something you need if you’re using SAM-e as consistently as you would a prescription drug. Definitely recommend! Review: Focus - I started taking these for focus and mood. The difference is subtle but allows me to stay focused when my typical afternoon slump hits. Before was fighting to get things done in the afternoons, now it takes a moderate amount of effort even when I feel tired. I also feel more motivated on the weekends. Instead of staring at my to-do list and maybe getting one thing checked off, I can get through a reasonable number without losing steam. No stomach or other side effects. ## Features - SAMe-Butanedisulfonate is a natural metabolite that participates in over 100 essential biochemical reactions in the cells of all animals. SAMe donates molecules to help manufacture the neurotransmitters (serotonin, norepinephrine, dopamine) involved in mood regulation as well as other necessary metabolites. So, rather than artificially altering the way that neurotransmitters are released or taken up by neurons, SAMe helps the body build more neurotransmitter molecules. - SAMe oxidizes rapidly when exposed to air, so, in order to maintain potency, SAMe tablets must be manufactured very carefully, enterically coated, and preserved in individual foil blister packs. Those who have tried Azendus-Butanedisulfonate have seen a noticeable difference to other generic SAMe-Tosylate form. - SAMe-Butanedisulfonate does not cause any weight gain or sexual dysfunction. - Azendus customers have been able to reduced daily dosages, when compared to other generic SAMe due to Azendus-Butanedisulfonate potency and bioavailability. Adjust your daily dosage intake, as required. - 400mg (S-Adendosylmethionine Butanedisulfonate) Plant Based Enteric Coated Tablets No plasticizers, synthetic co-polymers or artificial colors Gentle Stomach Formula - NATURAL SAMe Stable & Bioavailable Butanedisulfonate Form ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B01GK1YP7Q | | Best Sellers Rank | #170,077 in Health & Household ( See Top 100 in Health & Household ) #7,515 in Blended Vitamin & Mineral Supplements | | Brand | extreme V | | Brand Name | extreme V | | Customer Reviews | 4.4 out of 5 stars 199 Reviews | | Dosage Form | Tablet | | Flavor | Unflavored | | Item Form | Tablet | | Manufacturer | extreme V | | Manufacturer Part Number | 899568002560 | | Material Features | Plant Based | | Number of Items | 1 | | Product Benefits | Brain Health Support | | Special Ingredients | Coenzyme Q | | Total Servings Per Container | 60 | | UPC | 899568002560 899568002034 | | Unit Count | 60 Count | ## Product Details - **Brand:** extreme V - **Dosage Form:** Tablet - **Flavor:** Unflavored - **Item Form:** Tablet - **Material Feature:** Plant Based - **Number of Items:** 1 - **Product Benefits:** Brain Health Support - **Servings per Container:** 60 - **Special Ingredients:** Coenzyme Q - **Unit Count:** 60 Count ## Images ![Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/81FMG4y1jTL.jpg) ![Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets - Image 2](https://m.media-amazon.com/images/I/513PSdGsjHL.jpg) ![Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets - Image 3](https://m.media-amazon.com/images/I/51D9Ec3pDzL.jpg) ![Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets - Image 4](https://m.media-amazon.com/images/I/91KwWl0w05L.jpg) ![Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets - Image 5](https://m.media-amazon.com/images/I/61+LG2SWcKL.jpg) ## Customer Reviews ### ⭐⭐⭐⭐⭐ How SAMe compares to longtime antidepressants *by M***P on March 2, 2020* Taking 2 of the 400mg dose each morning for anxiety/depression (in other countries where SAM-e can be prescribed for such problems, 800mg is the standard MINIMUM dose and lower doses are usually ineffective). I’ve been on antidepressants of all different brands/kinds for 10 years now and they all have heavy side effects. Ultimately being emotionally blunted and losing any sense of motivation to do things I had to or even wanted to is what made me decide I had enough. However the nature of my particular problems are too serious to leave unchecked, so I started using this as soon as I worked down and got off the antidepressant, working up from the smallest dose over a month or two (be sure you’re off serotonin-altering medications like SSRIs or SNRIs before you start). Note that it will likely take a month or more to kick in, just like serotonin-altering medications. I chose this brand because it came up in research as one of the better brands you can get in the U.S., as it uses butanedisulfonate instead of the poorer quality tosylate that more commonly seen brands use (which were the ones I was familiar with from past dabbling at 200mg doses). I wish it wasn’t so costly but alas. Know that the 400mg pill is bigger than the 200mg one, multivitamin size. Unfortunately the 200 and 400mg boxes have no difference in box branding so make sure you’re getting the right dose and number of pills. I still have to take a different, non-antidepressant medication for a couple of the anxiety/sleep disorders, but the SAM-e has definitely taken the sharp edge off my anxiety and kept major depression away even through a very distressing life change, and without any noticeable side effects. It gives you enough help to keep you sane but doesn’t zombify you, letting you feel emotions (even if that can be hard at times) and learn coping strategies and healthy management of your disorders so that they can’t run your life anymore. Instead of being crutches like antidepressants, SAM-e is a handrail. You have to stand on your own two feet but you still have help so you don’t fall. Drugs are certainly stronger, but at more personal cost. What makes me like Azendus specifically is that when they accidentally sent me the wrong dosage and count days before I was about to run out they immediately got back to my return request (within an hour), refunded me, and sent me more with priority shipping at no cost to me. They were low on stock with the specific dose/count I typically get so they sent me enough of the 30 count to match up to my usual 60 count. I was very relieved and impressed by that and will definitely continue using this brand despite the lack of Prime shipping because I trust that honesty and reliability and that’s something you need if you’re using SAM-e as consistently as you would a prescription drug. Definitely recommend! ### ⭐⭐⭐⭐⭐ Focus *by M***M on April 15, 2024* I started taking these for focus and mood. The difference is subtle but allows me to stay focused when my typical afternoon slump hits. Before was fighting to get things done in the afternoons, now it takes a moderate amount of effort even when I feel tired. I also feel more motivated on the weekends. Instead of staring at my to-do list and maybe getting one thing checked off, I can get through a reasonable number without losing steam. No stomach or other side effects. ### ⭐⭐⭐⭐⭐ Measurably better anti-depressant effect than regular SAMe! *by S***T on January 30, 2019* Very pleased with the effectiveness of this formulation of SAMe! I have used other brands of SAMe for over 15 years to successfully manage moderate (but constant) depression and anxiety symptoms. Decided to try Azendus after I read that the form they manufacture has been shown more effective in research than the Tosylate form. Within a week I noticed a lift in mood and affect, after a month of feeling 25% more positive and clearly less anxious than the last 2 years, with no changes in external situations, I now know this form works much better for me! For those of us that manage to live with chronic depression, this is a breakthrough. Of course I also eat a healthy diet, exercise, make proper rest and sleep a priority, meditate and work on my responses to external triggers, but even with all that in place for years, this form of SAMe has made that extra, measurable difference between merely coping to actually feeling lighter-hearted! Very grateful to have found this. ## Frequently Bought Together - extreme V Azendus SAM-e Mood Support 400mg, 60 Count, Same Butanedisulfonate Fiber Enteric Coated Tablets - Simple Water Boost Hydrating Cleansing Wipes - 25 Wipes x 6 Pack (150 Wipes) - Core Power Elite High Protein Shake, Chocolate, 42g Bottle, 14oz, 12 Pack --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.ro/products/43039649-azendus-sam-e-mood-support-400mg-60-count-same-butanedisulfonate](https://www.desertcart.ro/products/43039649-azendus-sam-e-mood-support-400mg-60-count-same-butanedisulfonate) --- *Product available on Desertcart Romania* *Store origin: RO* *Last updated: 2026-05-16*