Klaire Labs Same 200 - Hypoallergenic 200 Milligrams Hypoallergenic S-adenosylmethionine with Enteric Coating to Support Mood, Liver Detoxification & Joints (60 Tablets)

I started taking SAMe for arthritis and back pain because I cannot take NSAIDs and really resist other drugs. When I read the clinical studies that my doctor pointed me to, I was convinced. Within a week, I could feel the difference. It was truly remarkable. Before taking it, I would get up in the morning and could barely walk to the bathroom - feet, ankles, knees, hips, back were excruciating and stiff. Now I get out of bed like I used to before the arthritis and practically jog to the bathroom. I feel great the rest of the day as well - no stiffness when getting out of the car or standing up from my desk. It is almost too good to be true! I bought the Prothera brand because, although it is more expensive, it has the enteric coating my doctor recommended (keeps it from being digested in the stomach and allows it to be absorbed in the small intestine), and because it doesn't have food dyes like other brands do.

Relieves dizziness & improves mood without side effects.

sent back made me vomit

I switched to this brand of SAMe at my doctors request. And I have to tell you I notice a difference. I'm super happy with this product.

I have tried different SAM-e brands and initially it seemed great but I went off SAM-e for a short time because I became ill (congested and headaches) which were relived when I stopped SAM-e. There is ample research indicating the benefits of SAM-e and neurologically I wanted the benefits because Alzheimer's runs in my family and I am a postgrad student. So, I tried SAM-e again and found I was unable to wake up the next day, note this did not happen with the Klaire brand, but I did experience intense irritability and my joint pain worsened when I took it which really conflicts with what I had experienced & read regarding the mechanism of action.I know about the vitamin B6 & B12 supplementation and I take a methylated B-vitamin in addition to other Thorne brand supplements that maintain my health. The things that concern me about SAM-e is the research I have read regarding Pneumocystis pneumonia in the lungs of non-HIV patients using SAM-e for growth. The Mayo Clinic cautions about this online. Second, I am worried about homocysteine increasing since in my case many of the symptoms I experienced were similar to a high homocysteine state when taking SAM-e again (the increased need for sleep, the inflammatory join pain, the anxiety/irritability and brain fog) regardless of my supplementation. I keep trying SAM-e again because I'm hopeful I will experience the benefits again without the pitfalls but I have yet to see benefit. So, I am writing this mostly to confirm that SAM-e is not for everyone apparently and to advise caution esp with those who have a MTHFR variant; are immunosuppressed; or, have a history of fungal & yeast infections. I think mitochondrial supplements (acetyl l-carnitine, PC, PS), glutathione, a clean diet & quality fish oil with Coenzyme Q10 & yoga helps me the most but to each his/her own.

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