With every application the skin is soothed, smoothed, restored and protected. Panthenol and Niacinamide work together to banish redness and dark spots. They lend a helping hand to those with acne. CoQ10 and rose balance and protect against free radicals, while MSM rebuilds and maintains the skin from the inside out. While soothing and cooling aloe and cucumber help keep things irritation free. The results are clear, blemish and dark-spot-free skin. Directions for Use: Apply to clean skin morning and/or night. Can be worn under makeup. RESEARCH ARTICLE: Improvement of acne vulgaris by topical fullerene application: unique impact on skin care Abstract Oxidative stress plays a major role in acne formation, suggesting that oxygen radical scavengers are potential therapeutic agents. Fullerene is a spherical carbon molecule with strong radical sponge activity; therefore, we studied the effectiveness of fullerene gel in treating acne vulgaris. We performed an open trial using a fullerene gel twice a day; at 4 and 8 weeks, the mean number of inflammatory lesions (erythematous papules and pustules) significantly (P < 0.05) decreased from 16.09 ± 9.08 to 12.36 ± 7.03 (reduction rate 23.2%) and 10.0 ± 5.62 (reduction rate 37.8%), respectively. The number of pustules, consisting of accumulation of neutrophils, was significantly (P < 0.05) decreased from 1.45 ± 1.13 to 0.18 ± 0.60 (reduction rate 87.6%), and further in vitro assays of sebum production in hamster sebocytes revealed that 75 μM polyvinylpyrrolidone-fullerene inhibits sebum production, suggesting that fullerene suppresses acne through decreasing neutrophil infiltration and sebum production. After treatment for 8 weeks, the water content of the skin significantly (P < 0.05) increased from 51.7 ± 7.9 to 60.4 ± 10.3 instrumental units. Therefore, the fullerene gel may help in controlling acne vulgaris with skin care benefit.
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