PUREX Technology Ergonomic Vertical Wired Mouse Supports 600/1000/1600 DPI, Backward/Forward Control Thumb Buttons, Removable Palm Rest - Reduces Wrist and Forearm Discomfort - PXE-M618BU

I own two of these now. One for my work computer and one at home. This specific model is very comfortable and easy to move. I use mouse pads from Cafe Press because they have thick rubber bottoms, large pad areas and an easy gliding surface for this mouse. Non glossy which I prefer. The mouse fits my had perfectly. Others who try to use my mouse catch on quickly although they don't need the ergo design. It is nice looking as well. My first one is still going strong and has lasted a few years now. Great purchase that I would recommend over the high end ergo mouse models that didn't work for me because my hand did not fit well and I don't feel my hand molded into it like it does this one. This one seems lighter than the other high end ones too.

As an IT professional, I really need an ergonomic mouse, as I am on a computer for 10-18 hours a day (OK some of that is gaming at home!). The thing I like about this mouse is the (removable) hand rest at the bottom, so your hand never touches the mousepad/desktop, making it far easier to glide it around. I have been using it for nine hours a (week)day since I got it and it is awesome!

I love this. It did wonders for my tendinitis. It keeps my wrist neutral so I’m not chronically putting strain on my wrist by twisting it.

Strange to start with, this mouse puts your hand in a stress free orientation. It sort of feels like a joystick. Quality seems good. I did not like the tailpiece it came with but it is easily detached. Overall a good purchase

No software to disable buttons. My thumb kept hitting the back button and would make my browser load the previous page, all the time.

I bought two and tried on different computers at home. I have more than 1 mouse connected. The scroll wheel does not work for scrolling purposes.