

🛡️ Protect your XL best friend like a pro—because pests don’t take breaks!
FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs (89-132 lbs) delivers fast-acting, waterproof protection that kills fleas, flea eggs, larvae, chewing lice, and ticks for a full 30 days. Featuring fipronil and (S)-methoprene, it disrupts the flea life cycle to prevent reinfestation. Trusted by pet owners for over 20 years, this easy-to-apply topical treatment continuously replenishes through sebaceous glands, ensuring lasting defense even if your dog gets wet.


















| Active Ingredients | fipronil and (S)-methoprene |
| Brand | Frontline |
| Customer Reviews | 4.4 out of 5 stars 15,120 Reviews |
| Item Form | Liquid |
| Item Volume | 302.4 Milliliters |
| Item Weight | 1.6 Ounces |
| Scent | Unscented |
T**E
This stuff still works great
I bought this because I remember, this was the first thing that came out to kill fleas & ticks! I haven't seen any in years! I'm glad I found it on Amazon! Because I can't afford the other stuff & too! The other stuff I don't really trust it much! This is well worth the money, & has worked great on my 116 pound German shepherd, yup she could lose a few pounds. But she's not scratched for fleas.. she does have dry skin. There was no smell & always fell safe applying the tube opening it away from me & applying it between the shoulder's! So thankful they still make Frontline & it works! Am definitely going to be buying more!
S**H
Still works in my part of the state
Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...
M**Y
Don’t waste your time and money on this.
Didn’t work at all! Shouldn’t have wasted the time or money on this! Ended up having to go to my vet and buying a different product! From what I’ve been told frontline has been around so long fleas are resistant to it now. Wish I could get my money back on it. Just glad that after talking to my vet and getting a different product my pets are comfortable and doing well!
D**S
Many uses- goat & swine mange, chicken mites, dogs.
Fantastic for feather and leg mites in chickens, scales start falling off within days, can take a few treatments for bad infestations. Slather with neem oil also to suffocate the mites between treatments. A lot of vets recommend this off label for mange in goats, swine and camelids and it works wonderfully. Treat, then treat again in 2-4 weeks. Hair starts growing back within a few days. In 2 weeks you can hardly tell but treat again or the mites come back since the eggs are hatching- get them on a mineral buffet as well so they can balance their systems and immunity to pests. However it is not lasting the 30 days it used to for fleas in dogs. Fleas were gone for about a week after treatment. Then one or 2 started appearing again. I am going to treat dogs for fleas every 2 weeks.This is the reason for 4 stars. I buy this plus size to treat 4 small 25lb dogs. It works great for chicken leg mites and feather mites, youtube videos show you how to apply, a drop on each leg, around vent, back of neck etc. Fantastic for mange in goats and llamas- use the same weight used for a dog.
K**J
Best flea and tick med!
Arrived quickly. Always works so well for fleas and ticks for our 2 German Shepherds (very thick hair). We live on lots of land with woods so they come into contact with fleas/ticks, but when Frontline is used, we don’t have any problems. Love the bigger pack that is offered and at the best price!! Fleas: No fleas on our dogs! Ease of application: Just takes a few seconds to apply!
A**Y
Good product
Product works well, I live in Florida, off grid, in the woods. We have lots of sand, and my lab is active and always playing in the forest. I never have problems with ticks or fleas. Nats are still a pain, but I use Avons, Skin So Soft, I spray it on my hands, lightly pass over her eyes, back and tail. I've never seen skin or eye irritation from any of my dogs. From the flea control or the Skin so soft. Hope this helps.
A**R
Wouldn’t recommend ,
I don’t know if they change the formula or what happened but for some reason it does not work anymore. We were using this every month to treat our dogs and they still had fleas. Do not recommend this at least not for tough environments like Florida.
J**K
A must have for my dogs
I have been using Frontline for years and will continue to do so. The ease of application and the protection it provides has been favored by me and my dogs. I usually by a 3 month supply for each of my dogs. It is becomes clear if I forget to give it my dogs. In my opinion each dose does last almost exactly one month. Usually I will notice the dogs starting to scratch if I forget. As soon as I apply, by the end of the day, the scratching will stop. I love knowing my dogs are protected. I have a lot of stray cats that invade my yard and they always carry fleas so knowing my dogs get what they need to reduce the fleas is essential. To apply, I break of the top of each little vial and apply directly on the skin above their shoulders. The dogs dont even notice. It is very easy. My dogs don't like taking anything in a pill form and just spit them out, so having this where I apply topical is better for me. I highly recommend. This product works and I don't think you will be disappointed. I will add to make sure you use the right product which is determined by the weight of your pet. I don't know, nor do I want to find out if I give my 70lb dog the same product as my 120lb. Just buy the one that is designed for the weight of your dog. Other than that, I highly recommend.
Trustpilot
3 weeks ago
3 days ago