Renue By ScienceTMG | High Strength TMG Supplements | 120 Trimethylglycine Capsules - 900mg TMG per Serving with Vitamin B12 Vitamin B6 Folate & Zinc | Made in The USA & Third-Party Tested

This is the best supplement iv ever used. You rarely take a supplement that you can FEEL makes a difference in a week/dayThis is absolutely one of them. From athletic performance to just day to day cognitive performance

This is a methylated supplement that includes 1000 mcg of methylated folate and B6. These capsules are acid resistant Enteric capsules that survive the acidic environment of the stomach, releasing their payload only in the alkaline environment of the small intestine for maximum uptake.

Part of my pre-workout stack. Noticeable effects on stamina and recovery. Very worthwhile supplement.

I am new to the TMG part of this supplement but the rest of it, I already take on a daily basis. The recommended dose is 2 capsules per day and there are 120 capsules in the bottle, making this bottle last about 2 months. Currently, the pills are about 26 cents each so not too expensive per day if you take the recommended dose.Mine are fresh as they were manufactured in 2024 but I don't see the best by date on my bottle. I like that it has a flip top lid, but I don't have little ones at home to worry about getting into my pills. The capsules are fairly small and easy to swallow. They have no taste or odor. I would get them again if I continue to like the TMG aspect of this capsule.

Dietary supplements, such as this Renue By Science TMG Methylation Essentials (Trimethylglycine) are not subject to FDA testing or certification. Because of that, it's up to the customers to do some research on the company they are buying from.I did my standard check on the product, by checking that the packaging is of high quality. This one passes with flying colors. Everything is properly labeled on the outside of the package, and the inner safety seal was properly applied. When I opened the safety seal I was not met with any strong smell. No smell at all. That's a good thing. The capsules are of normal size that I had no trouble swallowing.I've taken two capsules per day for the last two days with no adverse effects. I'll have to keep taking them for a bit longer before I will know if they are doing any good.The rest of the company history looks good. They have been in business since 2009 and the Better Business Bureau in their home city of Jacksonville FL has had 4 complaints on them in all that time. That's not very many. The company responded to all four complaints. There was only one complaint that involved an adverse reaction to the product, and that was a face cream, not a capsule that you swallow. The other complaints were involving shipping issues or a missing product accessory.My criteria for using a dietary supplement is that the company has to adhere to the packaging safety standards and have a good reputation. Renue By Science meets those qualifications , which is why I've been taking their capsules for the last two days and will continue to do, so I can tell if they give me positive results.My plan is to revisit this review once I've been on the capsules for a few weeks at least.

I had a talk with a naturopath recently about TMG and how many different benefits claim to be felt by users. He told me he'd had good results and encouraged me to give them a try. I've been taking these in the midday before lunch and have not had any stomach issues or ill effects. I do find my afternoon energy slump has dissipated. Made in the US and GMP certified helps to assure these are good quality. The bottle has sixty servings so lasts a couple months. I'm pleased with the results so far and will keep taking these.

These are of good quality and easy to take. I've waited to leave a review till over taken these a while. These do not hurt my stomach and I feel like I have less brain fog and more energy.

My interest in this product was peaked by its inclusion of supplements I already take on a daily basis, combined with TMG (trimethylglycine) which I hadn't tried previously. I've been consuming methyl B12 (methylcobalamin) and methyl folate since being prescribed these several years ago, and am currently taking 1000mg of each every morning, conveniently corresponding with the amount contained in each serving size of Methylation Essentials. With respect to B6, however, I've been taking the P-5-P (pyridoxal-5-phosphate) form rather than the form provided by this product, pyridoxine HCL. There are several forms of B6, and the reason I take this form is the same reason I take methyl B12 and methyl folate: I have the MTHFR gene mutation. I'm not sure why a product catered to methylation support would include pyridoxine HCL, especially because supplementation of pyridoxine HCL can lead to decreased B6 function. As explained by a paper available from the National Library of Medicine via PubMed entitled "The vitamin B6 paradox", symptoms of vitamin B6 supplementation are similar to those of B6 deficiency because the inactive form pyridoxine HCL competitively inhibits P-5-P. This product only contains 5.1mg per serving compared to the 50mg that I typically take, but it still seems counterintuitive to include this supplement in this product. After researching TMG prior to placing my order, I've come to realize that I should be consuming glycine in the evening rather than in the morning because it supports sleep, and that I should be consuming TMG in the morning because it provides energy. Since flipping my daily consumption of glycine to the evening and starting to take TMG, I've surprisingly noticed my energy levels increase.